Duhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration

Ye-Hui Wang; Yi Zhou; Xiang Gao; Sheng Sun; Yi-Zhou Xie; You-Peng Hu; Yang Fu; Xiao-Hong Fan; Quan Xie

doi:10.1371/journal.pone.0290925

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Open Access

Peer-reviewed

Research Article

Duhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration

Ye-Hui Wang ,

Contributed equally to this work with: Ye-Hui Wang, Yi Zhou

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Software, Writing – original draft

Affiliations Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China, Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, China
⨯
Yi Zhou ,

Contributed equally to this work with: Ye-Hui Wang, Yi Zhou

Roles Funding acquisition, Methodology

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
⨯
Xiang Gao ,

Roles Data curation

¶‡ These authors also contributed equally to this work.

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
⨯
Sheng Sun ,

Roles Methodology

¶‡ These authors also contributed equally to this work.

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
⨯
Yi-Zhou Xie ,

Roles Software

¶‡ These authors also contributed equally to this work.

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
⨯
You-Peng Hu,

Roles Data curation

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
⨯
Yang Fu,

Roles Supervision

Affiliation Chongqing Traditional Chinese Medicine Hospital, Chongqing, China
⨯
Xiao-Hong Fan ,

Roles Funding acquisition, Supervision, Writing – review & editing

* E-mail: 2186118231@qq.com (X-HF); 87517964@qq.com (QX)

Affiliation Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China

https://orcid.org/0009-0007-3155-155X

⨯
Quan Xie

Roles Data curation, Project administration

* E-mail: 2186118231@qq.com (X-HF); 87517964@qq.com (QX)

Affiliation Sichuan Province Orthopedic Hospital, Chengdu, Sichuan, China
⨯

Duhuo Jisheng Decoction regulates intracellular zinc homeostasis by enhancing autophagy via PTEN/Akt/mTOR pathway to improve knee cartilage degeneration

Ye-Hui Wang,
Yi Zhou,
Xiang Gao,
Sheng Sun,
Yi-Zhou Xie,
You-Peng Hu,
Yang Fu,
Xiao-Hong Fan,
Quan Xie

Published: January 2, 2024
https://doi.org/10.1371/journal.pone.0290925

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Chondrocytes
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Autophagic cell death
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Cartilage
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Apoptosis
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Quantitative analysis
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Ligaments
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Zinc
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Articular cartilage
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