Levels and in vitro functional effects of circulating anti-hinge antibodies in melanoma patients receiving the immune checkpoint inhibitor pembrolizumab

Barry D. Hock; Liping Goddard; Sean A. MacPherson; Matthew Strother; David Gibbs; John F. Pearson; Judith L. McKenzie

doi:10.1371/journal.pone.0290793

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Open Access

Peer-reviewed

Research Article

Levels and in vitro functional effects of circulating anti-hinge antibodies in melanoma patients receiving the immune checkpoint inhibitor pembrolizumab

Barry D. Hock ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: barry.hock@otago.ac.nz

Affiliation Haematology Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch Hospital, Christchurch, New Zealand

https://orcid.org/0000-0002-1329-367X

⨯
Liping Goddard,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Haematology Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch Hospital, Christchurch, New Zealand
⨯
Sean A. MacPherson,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliations Haematology Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch Hospital, Christchurch, New Zealand, Haematology Department, Christchurch Hospital, Christchurch, New Zealand
⨯
Matthew Strother,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Canterbury Regional Cancer and Haematology Service, Christchurch, New Zealand
⨯
David Gibbs,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Canterbury Regional Cancer and Haematology Service, Christchurch, New Zealand
⨯
John F. Pearson,

Roles Formal analysis, Writing – review & editing

Affiliation Biostatistics and Computational Biology Unit, University of Otago, Christchurch, Christchurch, New Zealand
⨯
Judith L. McKenzie

Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliation Haematology Research Group, Department of Pathology and Biomedical Science, University of Otago, Christchurch, Christchurch Hospital, Christchurch, New Zealand
⨯

Levels and in vitro functional effects of circulating anti-hinge antibodies in melanoma patients receiving the immune checkpoint inhibitor pembrolizumab

Barry D. Hock,
Liping Goddard,
Sean A. MacPherson,
Matthew Strother,
David Gibbs,
John F. Pearson,
Judith L. McKenzie

Published: September 15, 2023
https://doi.org/10.1371/journal.pone.0290793

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