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Open Access

Peer-reviewed

Research Article

Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression

Jian Yang ,

Contributed equally to this work with: Jian Yang, Jingjing Zhang

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jiany@sxmu.edu.cn

Affiliations Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, PR China, Department of Cell Biology and Genetics, College of Basic Medicine, Shanxi Medical University, Taiyuan, Shanxi, PR China

https://orcid.org/0000-0002-8233-9782

⨯
Jingjing Zhang ,

Contributed equally to this work with: Jian Yang, Jingjing Zhang

Roles Data curation, Investigation, Methodology, Project administration, Resources

Affiliation Department of Physiology, College of Basic Medicine, Shanxi Medical University, Taiyuan, Shanxi, PR China
⨯
Jingtian Chen,

Roles Data curation, Investigation, Methodology, Software

Affiliation Department of Colorectal Surgery, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi, PR China
⨯
Xiaolong Yang,

Roles Investigation, Methodology

Affiliation Department of Cell Biology and Genetics, College of Basic Medicine, Shanxi Medical University, Taiyuan, Shanxi, PR China
⨯
Hui Sun,

Roles Formal analysis, Investigation, Software, Supervision, Writing – original draft

Affiliation Science & Technology Information and Strategy Research Center of Shanxi, Taiyuan, Shanxi, PR China
⨯
Zhenxiang Zhao,

Roles Investigation, Software, Supervision

Affiliation Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, PR China
⨯
Hui Zhou,

Roles Methodology, Writing – original draft

Affiliation Translational Medicine Research Center, Shanxi Medical University, Taiyuan, Shanxi, PR China
⨯
Hao Shen

Roles Data curation, Methodology, Resources, Software

Affiliation College of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi, PR China
⨯

Thymidylate synthase promotes esophageal squamous cell carcinoma growth by relieving oxidative stress through activating nuclear factor erythroid 2-related factor 2 expression

Jian Yang,
Jingjing Zhang,
Jingtian Chen,
Xiaolong Yang,
Hui Sun,
Zhenxiang Zhao,
Hui Zhou,
Hao Shen

x

Published: September 8, 2023
https://doi.org/10.1371/journal.pone.0290264

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Cell proliferation
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Esophageal cancer
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Antioxidants
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