Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Xiaoya Niu; Yi Fu; Lei Feng; Maodi Xie; Bei Li; Lin Que; Zhen You

doi:10.1371/journal.pone.0290237

Loading metrics

Open Access

Peer-reviewed

Research Article

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Xiaoya Niu,

Roles Conceptualization, Writing – original draft, Writing – review & editing

Affiliations Department of General Surgery, Division of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China, Research Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China
⨯
Yi Fu,

Roles Data curation, Methodology

Affiliation Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China
⨯
Lei Feng,

Roles Investigation, Methodology

Affiliations Department of General Surgery, Division of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China, Research Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China
⨯
Maodi Xie,

Roles Investigation, Methodology

Affiliation West Chia-Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China
⨯
Bei Li,

Roles Data curation, Formal analysis

Affiliations Department of General Surgery, Division of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China, Research Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China
⨯
Lin Que,

Roles Data curation, Formal analysis

Affiliations Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China, State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610041, China
⨯
Zhen You

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: youzhen@wchscu.cn

Affiliations Department of General Surgery, Division of Biliary Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China, Research Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China

https://orcid.org/0000-0002-9792-7747

⨯

Upper-critical solution temperature (UCST) polymer functionalized nanomedicine for controlled drug release and hypoxia alleviation in hepatocellular carcinoma therapy

Xiaoya Niu,
Yi Fu,
Lei Feng,
Maodi Xie,
Bei Li,
Lin Que,
Zhen You

Published: August 25, 2023
https://doi.org/10.1371/journal.pone.0290237

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lasers
Is the Subject Area "Lasers" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Near-infrared spectroscopy
Is the Subject Area "Near-infrared spectroscopy" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Cytotoxicity
Is the Subject Area "Cytotoxicity" applicable to this article?

Thanks for your feedback.
Nanoparticles
Is the Subject Area "Nanoparticles" applicable to this article?

Thanks for your feedback.