Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis)

Vinzon Ibanez; Kestis Vaitkus; Maria Armila Ruiz; Zhengdeng Lei; Mark Maienschein-Cline; Zarema Arbieva; Donald Lavelle

doi:10.1371/journal.pone.0289860

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Peer-reviewed

Research Article

Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis)

Vinzon Ibanez ,

Contributed equally to this work with: Vinzon Ibanez, Kestis Vaitkus

Roles Investigation, Methodology, Writing – original draft

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Jesse Brown VA Medical Center, Chicago, Illinois, United States of America
⨯
Kestis Vaitkus ,

Contributed equally to this work with: Vinzon Ibanez, Kestis Vaitkus

Roles Investigation, Methodology

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Jesse Brown VA Medical Center, Chicago, Illinois, United States of America
⨯
Maria Armila Ruiz,

Roles Investigation, Methodology

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Jesse Brown VA Medical Center, Chicago, Illinois, United States of America
⨯
Zhengdeng Lei,

Roles Data curation, Formal analysis, Methodology

Affiliations Research Informatics Core, University of Illinois at Chicago, Chicago, Illinois, United States of America, Ambry Genetics, Aliso Viejo, California, United States of America
⨯
Mark Maienschein-Cline,

Roles Data curation, Methodology, Resources

Affiliation Research Informatics Core, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Zarema Arbieva,

Roles Methodology, Resources

Affiliation Genomics Research Core, University of Illinois at Chicago, Chicago, Illinois, United States of America
⨯
Donald Lavelle

Roles Conceptualization, Investigation, Supervision, Writing – original draft

* E-mail: dlavelle@uic.edu

Affiliations Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America, Jesse Brown VA Medical Center, Chicago, Illinois, United States of America

https://orcid.org/0000-0002-0275-7168

⨯

Effect of the LSD1 inhibitor RN-1 on γ-globin and global gene expression during erythroid differentiation in baboons (Papio anubis)

Vinzon Ibanez,
Kestis Vaitkus,
Maria Armila Ruiz,
Zhengdeng Lei,
Mark Maienschein-Cline,
Zarema Arbieva,
Donald Lavelle

Published: December 22, 2023
https://doi.org/10.1371/journal.pone.0289860

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Gene expression
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Cell differentiation
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DNA methylation
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Primates
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