DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells

XiaoLin Sun; Kai Jin; Xiangwei Ding; Zhongbao Ruan; Pei Xu

doi:10.1371/journal.pone.0289510

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Open Access

Peer-reviewed

Research Article

DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells

XiaoLin Sun ,

Contributed equally to this work with: XiaoLin Sun, Kai Jin, Xiangwei Ding

Roles Data curation, Formal analysis, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People’s Republic of China
⨯
Kai Jin ,

Contributed equally to this work with: XiaoLin Sun, Kai Jin, Xiangwei Ding

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software

Affiliation Department of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People’s Republic of China
⨯
Xiangwei Ding ,

Contributed equally to this work with: XiaoLin Sun, Kai Jin, Xiangwei Ding

Roles Data curation, Formal analysis, Project administration, Supervision

Affiliation Department of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People’s Republic of China
⨯
Zhongbao Ruan,

Roles Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Cardiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People’s Republic of China
⨯
Pei Xu

Roles Formal analysis, Project administration, Writing – original draft, Writing – review & editing

* E-mail: 106938907@qq.com

Affiliation Department of Haematology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu, The People’s Republic of China

https://orcid.org/0000-0002-4276-9622

⨯

DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells

XiaoLin Sun,
Kai Jin,
Xiangwei Ding,
Zhongbao Ruan,
Pei Xu

Published: August 29, 2023
https://doi.org/10.1371/journal.pone.0289510

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DNA methylation
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Promoter regions
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Cell differentiation
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Transcription factors
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Transcriptional control
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Histones
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Pacemakers
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Transfection
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