DNA and protein methyltransferases inhibition by adenosine dialdehyde reduces the proliferation and migration of breast and lung cancer cells by downregulating autophagy

Rose Ghemrawi; Aya Al Qassem; Azza Ramadan; Raghad Aldulaymi; Nour Sammani; Walaa K. Mousa; Mostafa Khair

doi:10.1371/journal.pone.0288791

Loading metrics

Open Access

Peer-reviewed

Research Article

DNA and protein methyltransferases inhibition by adenosine dialdehyde reduces the proliferation and migration of breast and lung cancer cells by downregulating autophagy

Rose Ghemrawi ,

Contributed equally to this work with: Rose Ghemrawi, Aya Al Qassem

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: rose.ghemrawi@aau.ac.ae

Affiliations College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates, AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates

https://orcid.org/0000-0002-2465-0812

⨯
Aya Al Qassem ,

Contributed equally to this work with: Rose Ghemrawi, Aya Al Qassem

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliations College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates, AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates
⨯
Azza Ramadan,

Roles Conceptualization, Writing – review & editing

Affiliations College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates, AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates
⨯
Raghad Aldulaymi,

Roles Methodology

Affiliation AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates
⨯
Nour Sammani,

Roles Methodology

Affiliations College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates, AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates
⨯
Walaa K. Mousa,

Roles Methodology, Writing – review & editing

Affiliations College of Pharmacy, Al Ain University, Abu Dhabi, United Arab Emirates, AAU Health and Biomedical Research Center, Al Ain University, Abu Dhabi, United Arab Emirates, College of Pharmacy, Mansoura University, Mansoura, Egypt
⨯
Mostafa Khair

Roles Methodology, Writing – review & editing

Affiliation Core Technology Platforms, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates
⨯

DNA and protein methyltransferases inhibition by adenosine dialdehyde reduces the proliferation and migration of breast and lung cancer cells by downregulating autophagy

Rose Ghemrawi,
Aya Al Qassem,
Azza Ramadan,
Raghad Aldulaymi,
Nour Sammani,
Walaa K. Mousa,
Mostafa Khair

Published: July 28, 2023
https://doi.org/10.1371/journal.pone.0288791

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
DNA methylation
Is the Subject Area "DNA methylation" applicable to this article?

Thanks for your feedback.
Methyltransferases
Is the Subject Area "Methyltransferases" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Cancer cell migration
Is the Subject Area "Cancer cell migration" applicable to this article?

Thanks for your feedback.
Prostate cancer
Is the Subject Area "Prostate cancer" applicable to this article?

Thanks for your feedback.