Gene regulation analysis of patient-derived iPSCs and its CRISPR-corrected control provides a new tool for studying perturbations of ELMOD3 c.512A>G mutation during the development of inherited hearing loss

• Xianlin Liu,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China

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• Jie Wen,

  Roles Conceptualization, Data curation, Investigation, Supervision, Validation, Writing – review & editing

  Affiliations Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China, Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China

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• Xuezhong Liu,

  Roles Conceptualization, Data curation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Otolaryngology, University of Miami Miller School of Medicine, Miami, FL, United States of America

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• Anhai Chen,

  Roles Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China

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• Sijun Li,

  Roles Data curation, Investigation, Supervision, Validation

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China

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• Jing Liu,

  Roles Formal analysis, Investigation, Software, Validation, Visualization

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China

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• Jie Sun,

  Roles Investigation, Methodology, Resources, Software

  Affiliation Department of Otolaryngology Head and Neck Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Futian District, Shenzhen, China

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• Wei Gong,

  Roles Data curation, Supervision, Validation

  Affiliations Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China, Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China

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• Xiaoming Kang,

  Roles Formal analysis, Supervision, Validation

  Affiliations Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China, Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China

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• Zhili Feng,

  Roles Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliations Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China, Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China

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• Chufeng He,

  Roles Conceptualization, Data curation, Investigation, Resources

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China

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• Lingyun Mei,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Key Laboratory of Otolaryngology Major Disease Research of Hunan Province, Changsha, Hunan, China

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• Jie Ling ,

  Roles Conceptualization, Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  * E-mail: lingjie@sklmg.edu.cn (JL); fengyong_hn@hotmail.com (YF)

  Affiliation Medical Functional Experiment Center, School of Basic Medical Science, Central South University, Changsha, Hunan, China

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• Yong Feng

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

  * E-mail: lingjie@sklmg.edu.cn (JL); fengyong_hn@hotmail.com (YF)

  Affiliations Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan, China, Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China, Institute of Otolaryngology Head and Neck Surgery, University of South China, Changsha, Hunan, China

  https://orcid.org/0000-0003-3824-3780

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