Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma

Jinyan Feng; Jinwu Wang; Yao Xu; Feng Lu; Jin Zhang; Xiuxin Han; Chao Zhang; Guowen Wang

doi:10.1371/journal.pone.0288180

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Open Access

Peer-reviewed

Research Article

Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma

Jinyan Feng ,

Contributed equally to this work with: Jinyan Feng, Jinwu Wang

Roles Data curation, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Jinwu Wang ,

Contributed equally to this work with: Jinyan Feng, Jinwu Wang

Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Yao Xu,

Roles Data curation, Formal analysis, Writing – original draft

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Feng Lu,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Jin Zhang,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Xiuxin Han,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Chao Zhang ,

Roles Data curation, Methodology, Writing – review & editing

* E-mail: Zhangchao198409@163.com (CZ); wangguowen@tmu.edu.cn (GW)

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China
⨯
Guowen Wang

Roles Funding acquisition, Project administration, Writing – review & editing

* E-mail: Zhangchao198409@163.com (CZ); wangguowen@tmu.edu.cn (GW)

Affiliations Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China, Tianjin’s Clinical Research Center for Cancer, Tianjin, China

https://orcid.org/0000-0003-0945-7579

⨯

Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma

Jinyan Feng,
Jinwu Wang,
Yao Xu,
Feng Lu,
Jin Zhang,
Xiuxin Han,
Chao Zhang,
Guowen Wang

Published: July 5, 2023
https://doi.org/10.1371/journal.pone.0288180

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Osteosarcoma
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Medical risk factors
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Gene expression
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Immune cells
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