Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9

• Paul L. Chariou,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

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• Christine M. Minnar,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

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• Mayank Tandon,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations National Cancer Institute, CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Institutes of Health, Bethesda, MD, United States of America, Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America

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• Mary R. Guest,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliation Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America

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• Raj Chari,

  Roles Data curation, Methodology, Software, Validation, Writing – review & editing

  Affiliation Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, United States of America

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• Jeffrey Schlom ,

  Contributed equally to this work with: Jeffrey Schlom, Sofia R. Gameiro

  Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: schlomj@mail.nih.gov

  Affiliation Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

  https://orcid.org/0000-0001-7932-4072

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• Sofia R. Gameiro

  Contributed equally to this work with: Jeffrey Schlom, Sofia R. Gameiro

  Roles Conceptualization, Data curation, Investigation, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States of America

  https://orcid.org/0000-0002-2392-8122

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