MicroRNA-29b-3p promotes intestinal permeability in IBS-D via targeting TRAF3 to regulate the NF-κB-MLCK signaling pathway

Yongfu Wang; Wei Ke; Jianfeng Gan; He Zhu; Xiangyu Xie; Guodong He; Shan Liu; Yusheng Huang; Hongmei Tang

doi:10.1371/journal.pone.0287597

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Open Access

Peer-reviewed

Research Article

MicroRNA-29b-3p promotes intestinal permeability in IBS-D via targeting TRAF3 to regulate the NF-κB-MLCK signaling pathway

Yongfu Wang ,

Contributed equally to this work with: Yongfu Wang, Wei Ke

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Traditional Chinese Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
⨯
Wei Ke ,

Contributed equally to this work with: Yongfu Wang, Wei Ke

Roles Formal analysis, Investigation, Writing – review & editing

Affiliations The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Jianfeng Gan,

Roles Investigation, Methodology

Affiliation The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
He Zhu,

Roles Funding acquisition, Methodology

Affiliation The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Xiangyu Xie,

Roles Software, Supervision

Affiliations The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Guodong He,

Roles Validation

Affiliations The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Shan Liu,

Roles Data curation, Supervision

Affiliations The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China, The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Yusheng Huang ,

Roles Project administration, Resources

* E-mail: yxb@gzucm.edu.cn (HT); hys1125@gzucm.edu.cn (YH)

Affiliations The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China
⨯
Hongmei Tang

Roles Funding acquisition, Project administration, Writing – review & editing

* E-mail: yxb@gzucm.edu.cn (HT); hys1125@gzucm.edu.cn (YH)

Affiliation The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China

https://orcid.org/0000-0001-6073-4389

⨯

MicroRNA-29b-3p promotes intestinal permeability in IBS-D via targeting TRAF3 to regulate the NF-κB-MLCK signaling pathway

Yongfu Wang,
Wei Ke,
Jianfeng Gan,
He Zhu,
Xiangyu Xie,
Guodong He,
Shan Liu,
Yusheng Huang,
Hongmei Tang

Published: July 10, 2023
https://doi.org/10.1371/journal.pone.0287597

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