Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

• Masaya Fukushi ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: mfukushi@hiroshima-u.ac.jp

  Affiliation Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

  https://orcid.org/0000-0002-1315-2877

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• Ryosuke Ohsawa,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Epidemiology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

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• Yasushi Okinaka,

  Roles Funding acquisition, Investigation

  Affiliation Graduate School of Integrated Sciences for Life, Hiroshima University, Higashi-Hiroshima City, Hiroshima, Japan

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• Daisuke Oikawa,

  Roles Resources

  Affiliation Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan

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• Tohru Kiyono,

  Roles Investigation

  Affiliation Project for Prevention of HPV-related Cancer, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Kashiwa, Chiba, Japan

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• Masaya Moriwaki,

  Roles Investigation

  Affiliation Department of Epidemiology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

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• Takashi Irie,

  Roles Funding acquisition, Investigation

  Affiliation Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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• Kosuke Oda,

  Roles Investigation

  Affiliation Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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• Yasuhiro Kamei,

  Roles Investigation

  Affiliation Spectrography and Bioimaging Facility, National Institute for Basic Biology, Okazaki, Aichi, Japan

  https://orcid.org/0000-0001-6382-1365

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• Fuminori Tokunaga,

  Roles Resources

  Affiliation Department of Medical Biochemistry, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan

  https://orcid.org/0000-0003-3626-9119

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• Yusuke Sotomaru,

  Roles Resources

  Affiliation Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan

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• Hirofumi Maruyama,

  Roles Resources

  Affiliation Department of Clinical Neuroscience & Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

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• Hideshi Kawakami,

  Roles Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Epidemiology, Research Institute of Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

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• Takemasa Sakaguchi

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

  https://orcid.org/0000-0002-3754-1252

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