Targeted randomization dose optimization trials enable fractional dosing of scarce drugs

• Philip S. Boonstra,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliations Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America, Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America

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• Alex Tabarrok,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Economics, George Mason University, Fairfax, Virginia, United States of America

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• Garth W. Strohbehn

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gstrohbe@umich.edu

  Affiliations Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America, Veterans Affairs Center for Clinical Management and Research, Ann Arbor, Michigan, United States of America, Institute for Health Policy and Innovation, University of Michigan, Ann Arbor, Michigan, United States of America, Division of Medical Oncology, LTC Charles S Kettles VA Medical Center, Ann Arbor, Michigan, United States of America, Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America

  https://orcid.org/0000-0003-2973-3040

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