A holistic view of muscle metabolic reprogramming through personalized metabolic modeling in newly diagnosed diabetic patients

Maryam Khoshnejat; Ali Mohammad Banaei-Moghaddam; Ali Akbar Moosavi-Movahedi; Kaveh Kavousi

doi:10.1371/journal.pone.0287325

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Open Access

Peer-reviewed

Research Article

A holistic view of muscle metabolic reprogramming through personalized metabolic modeling in newly diagnosed diabetic patients

Maryam Khoshnejat,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft

Affiliations Laboratory of Complex Biological Systems and Bioinformatics (CBB), Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran, The UNESCO Chair on Interdisciplinary Research in Diabetes, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
⨯
Ali Mohammad Banaei-Moghaddam ,

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

* E-mail: am_banaei@ut.ac.ir (AMBM); kkavousi@ut.ac.ir (KK)

Affiliations The UNESCO Chair on Interdisciplinary Research in Diabetes, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran, Laboratory of Genomics and Epigenomics (LGE), Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran

https://orcid.org/0000-0003-1298-3748

⨯
Ali Akbar Moosavi-Movahedi,

Roles Supervision, Writing – review & editing

Affiliations The UNESCO Chair on Interdisciplinary Research in Diabetes, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
⨯
Kaveh Kavousi

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: am_banaei@ut.ac.ir (AMBM); kkavousi@ut.ac.ir (KK)

Affiliations Laboratory of Complex Biological Systems and Bioinformatics (CBB), Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran, The UNESCO Chair on Interdisciplinary Research in Diabetes, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran

https://orcid.org/0000-0002-1906-3912

⨯

A holistic view of muscle metabolic reprogramming through personalized metabolic modeling in newly diagnosed diabetic patients

Maryam Khoshnejat,
Ali Mohammad Banaei-Moghaddam,
Ali Akbar Moosavi-Movahedi,
Kaveh Kavousi

Published: June 15, 2023
https://doi.org/10.1371/journal.pone.0287325

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Glucose metabolism
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Metabolites
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Insulin resistance
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Diabetes mellitus
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Gene expression
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Skeletal muscles
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Membrane metabolism
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Metabolic networks
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