Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

Daniel A. Kuppers; Jonathan Linton; Sergio Ortiz Espinosa; Kelly M. McKenna; Anthony Rongvaux; Patrick J. Paddison

doi:10.1371/journal.pone.0287052

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Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

Daniel A. Kuppers ,

Contributed equally to this work with: Daniel A. Kuppers, Jonathan Linton

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Jonathan Linton ,

Contributed equally to this work with: Daniel A. Kuppers, Jonathan Linton

Roles Investigation, Methodology, Validation

Affiliation Translational Science and Therapeutics Division, Program in Immunology, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Sergio Ortiz Espinosa,

Roles Investigation, Methodology, Validation

Affiliation Translational Science and Therapeutics Division, Program in Immunology, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

https://orcid.org/0000-0001-9192-2956

⨯
Kelly M. McKenna,

Roles Investigation, Methodology, Validation

Affiliation Translational Science and Therapeutics Division, Program in Immunology, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America
⨯
Anthony Rongvaux ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rongvaux@fredhutch.org (AR); paddison@fredhutch.org (PJP)

Affiliations Translational Science and Therapeutics Division, Program in Immunology, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America, Department of Immunology, University of Washington, Seattle, Washington, United States of America
⨯
Patrick J. Paddison

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rongvaux@fredhutch.org (AR); paddison@fredhutch.org (PJP)

Affiliation Human Biology Division, Fred Hutchinson Cancer Center, Seattle, Washington, United States of America

https://orcid.org/0000-0002-7144-0228

⨯

Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

Daniel A. Kuppers,
Jonathan Linton,
Sergio Ortiz Espinosa,
Kelly M. McKenna,
Anthony Rongvaux,
Patrick J. Paddison

Published: June 28, 2023
https://doi.org/10.1371/journal.pone.0287052

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