Evaluation of ¹⁸F labeled glial fibrillary acidic protein binding nanobody and its brain shuttle peptide fusion proteins using a neuroinflammation rat model

• Takahiro Morito,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

  Current address: Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, Japan

  Affiliations Division of Cyclotron Nuclear Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

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• Ryuichi Harada ,

  Roles Conceptualization, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: ryuichi.harada.c8@tohoku.ac.jp

  Affiliations Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan

  https://orcid.org/0000-0001-8538-8814

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• Ren Iwata,

  Roles Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Miyagi, Japan

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• Yoichi Ishikawa,

  Roles Resources, Writing – review & editing

  Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Miyagi, Japan

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• Nobuyuki Okamura,

  Roles Supervision, Writing – review & editing

  Affiliation Division of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan

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• Yukitsuka Kudo,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Institute of Development, Aging and Cancer, Tohoku University, Sendai, Miyagi, Japan

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• Shozo Furumoto,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Division of Radiopharmaceutical Chemistry, Cyclotron and Radioisotope Center, Tohoku University, Sendai, Miyagi, Japan

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• Kazuhiko Yanai,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Division of Cyclotron Nuclear Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan, Department of Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

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• Manabu Tashiro

  Roles Supervision, Writing – review & editing

  Affiliation Division of Cyclotron Nuclear Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

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