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Open Access
Peer-reviewed
Research Article
Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge
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Kelly L. Weaver ,
Contributed equally to this work with: Kelly L. Weaver, Graham J. Bitzer
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Graham J. Bitzer ,
Contributed equally to this work with: Kelly L. Weaver, Graham J. Bitzer
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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M. Allison Wolf,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Gage M. Pyles,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Megan A. DeJong,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Spencer R. Dublin,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Annalisa B. Huckaby,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Maria de la Paz Gutierrez,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Jesse M. Hall,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Ting Y. Wong,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Matthew Warden,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Jonathan E. Petty,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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William T. Witt,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Casey Cunningham,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Emel Sen-Kilic,
Roles Investigation, Writing – original draft, Writing – review & editing
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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F. Heath Damron ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: mabarbier@hsc.wvu.edu (MB); fdamron@hsc.wvu.edu (FHD)
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Mariette Barbier
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: mabarbier@hsc.wvu.edu (MB); fdamron@hsc.wvu.edu (FHD)
Affiliation Vaccine Development Center in the Department of Microbiology, Immunology, and Cell Biology at West Virginia University, Morgantown, WV, United States of America
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Intranasal challenge with B. pertussis leads to more severe disease manifestations in mice than aerosol challenge
- Kelly L. Weaver,
- Graham J. Bitzer,
- M. Allison Wolf,
- Gage M. Pyles,
- Megan A. DeJong,
- Spencer R. Dublin,
- Annalisa B. Huckaby,
- Maria de la Paz Gutierrez,
- Jesse M. Hall,
- Ting Y. Wong
- Published: November 2, 2023
- https://doi.org/10.1371/journal.pone.0286925