The VIPR2-selective antagonist KS-133 changes macrophage polarization and exerts potent anti-tumor effects as a single agent and in combination with an anti-PD-1 antibody

• Kotaro Sakamoto ,

  Contributed equally to this work with: Kotaro Sakamoto, Wararat Kittikulsuth

  Roles Conceptualization, Data curation, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: sakamoto-kotaro@ichimaru.co.jp

  Affiliation Research & Development Depertment, Ichimaru Pharcos Company Limited, Motosu, Gifu, Japan

  https://orcid.org/0000-0003-1295-1623

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• Wararat Kittikulsuth ,

  Contributed equally to this work with: Kotaro Sakamoto, Wararat Kittikulsuth

  Roles Conceptualization, Data curation

  Affiliation Depertment of Pharmacology, Faculty of Medcine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan

  ⨯
• Eijiro Miyako,

  Roles Conceptualization, Supervision

  Affiliation Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology, Nomi, Ishikawa, Japan

  ⨯
• Akumwami Steeve,

  Roles Data curation

  Affiliation Depertment of Pharmacology, Faculty of Medcine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan

  ⨯
• Rika Ishimura,

  Roles Data curation

  Affiliation Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan

  ⨯
• Shinsaku Nakagawa,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliations Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Science, Osaka University, Suita, Osaka, Japan, Laboratory of Biopharmaceutics, Osaka University, Suita, Osaka, Japan, Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan

  ⨯
• Yukio Ago,

  Roles Data curation, Supervision, Writing – review & editing

  Affiliations Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan, Department of Cellular and Molecular Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan

  https://orcid.org/0000-0001-7562-4000

  ⨯
• Akira Nishiyama

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Depertment of Pharmacology, Faculty of Medcine, Kagawa University, Miki-cho, Kita-gun, Kagawa, Japan

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