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Open Access
Peer-reviewed
Research Article
Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis
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Brooks P. Leitner,
Roles Conceptualization, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Department of Internal Medicine, Yale University, New Haven, Connecticut, United States of America
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Won D. Lee,
Roles Investigation, Methodology, Writing – review & editing
Affiliations Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America
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Wanling Zhu,
Roles Investigation
Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Department of Internal Medicine, Yale University, New Haven, Connecticut, United States of America
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Xinyi Zhang,
Roles Investigation
Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Department of Internal Medicine, Yale University, New Haven, Connecticut, United States of America
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Rafael C. Gaspar,
Roles Investigation
Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Department of Internal Medicine, Yale University, New Haven, Connecticut, United States of America
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Zongyu Li,
Roles Investigation
Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Department of Internal Medicine, Yale University, New Haven, Connecticut, United States of America
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Joshua D. Rabinowitz,
Roles Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliations Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Department of Chemistry, Princeton University, Princeton, New Jersey, United States of America, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America, Ludwig Institute for Cancer Research, Princeton Branch, Princeton, New Jersey, United States of America
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Rachel J. Perry
Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing
* E-mail: rachel.perry@yale.edu
Affiliations Department of Cellular & Molecular Physiology, Yale University, New Haven, Connecticut, United States of America, Department of Internal Medicine, Yale University, New Haven, Connecticut, United States of America
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Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis
- Brooks P. Leitner,
- Won D. Lee,
- Wanling Zhu,
- Xinyi Zhang,
- Rafael C. Gaspar,
- Zongyu Li,
- Joshua D. Rabinowitz,
- Rachel J. Perry
- Published: July 6, 2023
- https://doi.org/10.1371/journal.pone.0286525