Population genetic testing and SERPINA1 sequencing identifies unidentified alpha-1 antitrypsin deficiency alleles and gene-environment interaction with hepatitis C infection

• Bryce A. Schuler ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bryce.a.schuler@vumc.org

  Affiliations Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  https://orcid.org/0000-0001-9111-3702

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• Lisa Bastarache,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Janey Wang,

  Roles Funding acquisition, Project administration, Software, Writing – review & editing

  Affiliation Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Jing He,

  Roles Data curation, Formal analysis, Software, Validation, Writing – review & editing

  Affiliation Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Sara L. Van Driest ,

  Contributed equally to this work with: Sara L. Van Driest, Joshua C. Denny

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Joshua C. Denny

  Contributed equally to this work with: Sara L. Van Driest, Joshua C. Denny

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations All of Us Research Program, National Institutes of Health, Bethesda, Maryland, United States of America, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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