Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in Beagle dog plasma by UPLC–MS/MS and its application to a pharmacokinetic study

Xuefeng Zhang; Guanlan Liu; Zechun Sang; Qinglong Guo; Yuxin Zhou

doi:10.1371/journal.pone.0286467

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Peer-reviewed

Research Article

Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in Beagle dog plasma by UPLC–MS/MS and its application to a pharmacokinetic study

Xuefeng Zhang,

Roles Investigation, Project administration, Writing – original draft

Affiliations State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China, TriApex Laboratories Co., Ltd, Nanjing, People’s Republic of China
⨯
Guanlan Liu,

Roles Data curation, Methodology, Project administration, Visualization

Affiliation TriApex Laboratories Co., Ltd, Nanjing, People’s Republic of China
⨯
Zechun Sang,

Roles Data curation, Methodology, Project administration, Visualization

Affiliation TriApex Laboratories Co., Ltd, Nanjing, People’s Republic of China
⨯
Qinglong Guo ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: anticancer_drug@163.com (QG); zyxspain@hotmail.com (YZ)

Affiliation State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China
⨯
Yuxin Zhou

Roles Conceptualization, Data curation, Writing – review & editing

* E-mail: anticancer_drug@163.com (QG); zyxspain@hotmail.com (YZ)

Affiliation State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, Department of Physiology, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China

https://orcid.org/0000-0003-3219-8392

⨯

Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in Beagle dog plasma by UPLC–MS/MS and its application to a pharmacokinetic study

Xuefeng Zhang,
Guanlan Liu,
Zechun Sang,
Qinglong Guo,
Yuxin Zhou

Published: June 7, 2023
https://doi.org/10.1371/journal.pone.0286467

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