The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

Norman R. Watts; Elif Eren; Ira Palmer; Paul L. Huang; Philip Lin Huang; Robert H. Shoemaker; Sylvia Lee-Huang; Paul T. Wingfield

doi:10.1371/journal.pone.0286370

Loading metrics

Open Access

Peer-reviewed

Research Article

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

Norman R. Watts ,

Contributed equally to this work with: Norman R. Watts, Elif Eren

Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: wattsn@mail.nih.gov (NW); sylvia.lee-huang@med.nyu.edu (SLH)

Affiliation Protein Expression Laboratory, NIAMS, NIH, Bethesda, Maryland, United States of America

https://orcid.org/0000-0001-5089-635X

⨯
Elif Eren ,

Contributed equally to this work with: Norman R. Watts, Elif Eren

Roles Formal analysis, Investigation, Visualization

Affiliation Protein Expression Laboratory, NIAMS, NIH, Bethesda, Maryland, United States of America
⨯
Ira Palmer,

Roles Resources

Affiliation Protein Expression Laboratory, NIAMS, NIH, Bethesda, Maryland, United States of America
⨯
Paul L. Huang,

Roles Conceptualization

Affiliation Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Philip Lin Huang,

Roles Conceptualization

Affiliation Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Robert H. Shoemaker,

Roles Conceptualization, Resources

Affiliation Chemopreventive Agent Development Research Group, Division of Cancer Prevention, NCI, NIH, Bethesda, Maryland, United States of America
⨯
Sylvia Lee-Huang ,

Roles Conceptualization, Formal analysis, Supervision

* E-mail: wattsn@mail.nih.gov (NW); sylvia.lee-huang@med.nyu.edu (SLH)

Affiliation Department of Biochemistry and Molecular Pharmacology, New York University, Grossman School of Medicine, New York, New York, United States of America
⨯
Paul T. Wingfield

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Protein Expression Laboratory, NIAMS, NIH, Bethesda, Maryland, United States of America
⨯

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

Norman R. Watts,
Elif Eren,
Ira Palmer,
Paul L. Huang,
Philip Lin Huang,
Robert H. Shoemaker,
Sylvia Lee-Huang,
Paul T. Wingfield

Published: June 29, 2023
https://doi.org/10.1371/journal.pone.0286370

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

SARS CoV 2
Is the Subject Area "SARS CoV 2" applicable to this article?

Thanks for your feedback.
Cytotoxicity assay
Is the Subject Area "Cytotoxicity assay" applicable to this article?

Thanks for your feedback.
RNA structure
Is the Subject Area "RNA structure" applicable to this article?

Thanks for your feedback.
Cytotoxicity
Is the Subject Area "Cytotoxicity" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
HIV-1
Is the Subject Area "HIV-1" applicable to this article?

Thanks for your feedback.
Molecular dynamics
Is the Subject Area "Molecular dynamics" applicable to this article?

Thanks for your feedback.
Ribosomes
Is the Subject Area "Ribosomes" applicable to this article?

Thanks for your feedback.