Electron microscopy imaging and mechanical characterization of T47D multicellular tumor spheroids–Older spheroids reduce interstitial space and become stiffer

• Mathangi Madhavan ,

  Contributed equally to this work with: Mathangi Madhavan, Devina Jaiswal

  Roles Formal analysis, Investigation, Writing – original draft

  Affiliation Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States of America

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• Devina Jaiswal ,

  Contributed equally to this work with: Mathangi Madhavan, Devina Jaiswal

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States of America, Department of Biomedical Engineering, Western New England University, Springfield, Massachusetts, United States of America

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• Sarah Karlberg,

  Roles Investigation, Writing – original draft

  Affiliation Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States of America

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• Alexis Duggan,

  Roles Investigation, Writing – original draft

  Affiliation Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States of America

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• Hassan A. Almarshad,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology

  Affiliations Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States of America, College of Applied Medical Sciences, Al Jouf University, Sakakah, Al Jawf, Saudi Arabia

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• Kevin P. Claffey,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut, United States of America

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• Kazunori Hoshino

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: kazunori.hoshino@uconn.edu

  Affiliation Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut, United States of America

  https://orcid.org/0000-0002-7080-7825

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