Are rapid tests and confirmatory western blot used for cattle and small ruminants TSEs reliable tools for the diagnosis of Chronic Wasting Disease in Europe?

• Maria Mazza ,

  Contributed equally to this work with: Maria Mazza, Linh Tran

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: maria,mazza@izsto.it

  Affiliation European Reference Laboratory for Transmissible Spongiform Encephalopathies - Italian Reference Laboratory for Transmissible Spongiform Encephalopathies, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy

  https://orcid.org/0000-0002-7126-7875

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• Linh Tran ,

  Contributed equally to this work with: Maria Mazza, Linh Tran

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation World Organisation for Animal Health (WOAH, founded as OIE) - Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, Oslo, Norway

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• Daniela Loprevite,

  Roles Investigation, Resources

  Affiliation European Reference Laboratory for Transmissible Spongiform Encephalopathies - Italian Reference Laboratory for Transmissible Spongiform Encephalopathies, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy

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• Maria C. Cavarretta,

  Roles Investigation, Resources

  Affiliation European Reference Laboratory for Transmissible Spongiform Encephalopathies - Italian Reference Laboratory for Transmissible Spongiform Encephalopathies, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy

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• Daniela Meloni,

  Roles Conceptualization, Formal analysis

  Affiliation European Reference Laboratory for Transmissible Spongiform Encephalopathies - Italian Reference Laboratory for Transmissible Spongiform Encephalopathies, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy

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• Luana Dell’Atti,

  Roles Investigation

  Affiliation European Reference Laboratory for Transmissible Spongiform Encephalopathies - Italian Reference Laboratory for Transmissible Spongiform Encephalopathies, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy

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• Jørn Våge,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation World Organisation for Animal Health (WOAH, founded as OIE) - Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, Oslo, Norway

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• Knut Madslien,

  Roles Resources, Writing – review & editing

  Affiliation World Organisation for Animal Health (WOAH, founded as OIE) - Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, Oslo, Norway

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• Tram T. Vuong,

  Roles Writing – review & editing

  Affiliation World Organisation for Animal Health (WOAH, founded as OIE) - Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, Oslo, Norway

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• Elena Bozzetta ,

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Writing – review & editing

  ¶‡ EB and SLB also contributed equally to this work.

  Affiliation European Reference Laboratory for Transmissible Spongiform Encephalopathies - Italian Reference Laboratory for Transmissible Spongiform Encephalopathies, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Turin, Italy

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• Sylvie L. Benestad

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  ¶‡ EB and SLB also contributed equally to this work.

  Affiliation World Organisation for Animal Health (WOAH, founded as OIE) - Reference Laboratory for Chronic Wasting Disease, Norwegian Veterinary Institute, Oslo, Norway

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