Helicase-like transcription factor (Hltf)-deletion activates Hmgb1-Rage axis and granzyme A-mediated killing of pancreatic β cells resulting in neonatal lethality

• Gurvinder Kaur,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Medical Education, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Rebecca A. Helmer,

  Roles Data curation, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Current address: Garrison Independent School District, Garrison, Texas, United States of America

  Affiliation Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Dalia Martinez-Marin,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliations Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America, Department of Immunology and Molecular Microbiology, Texas Tech University-Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Souad R. Sennoune,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Rachel L. Washburn,

  Roles Conceptualization, Visualization, Writing – review & editing

  Affiliation Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Raul Martinez-Zaguilan,

  Roles Conceptualization, Visualization, Writing – review & editing

  Affiliation Department of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Jannette M. Dufour,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  ⨯
• Beverly S. Chilton

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

  * E-mail: Beverly.chilton@ttuhsc.edu

  Affiliation Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America

  https://orcid.org/0000-0002-8066-8697

  ⨯