Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer’s disease mice via suppressing TLR4 signaling pathway through the gut-brain axis

Yunfang Su; Dahui Wang; Ningning Liu; Jiajia Yang; Ruiqin Sun; Zhenqiang Zhang

doi:10.1371/journal.pone.0286086

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Peer-reviewed

Research Article

Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer’s disease mice via suppressing TLR4 signaling pathway through the gut-brain axis

Yunfang Su ,

Contributed equally to this work with: Yunfang Su, Dahui Wang

Roles Data curation, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliations Henan Engineering Research Center for Prevention and Treatment of Major Chronic Diseases with Chinese Medicine, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Dahui Wang ,

Contributed equally to this work with: Yunfang Su, Dahui Wang

Roles Data curation, Funding acquisition, Writing – original draft, Writing – review & editing

Affiliations LiangShan College (LiShui) China, Lishui University, Lishui, Zhejiang Province, China, Henan JinBaiHe Biotechnology Co. LTD, Nanjing, Jiangsu, China
⨯
Ningning Liu,

Roles Conceptualization, Writing – original draft

Affiliation Henan Engineering Research Center for Prevention and Treatment of Major Chronic Diseases with Chinese Medicine, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Jiajia Yang,

Roles Data curation

Affiliation School of Acupuncture and Massage, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Ruiqin Sun,

Roles Writing – review & editing

Affiliation Henan Engineering Research Center for Prevention and Treatment of Major Chronic Diseases with Chinese Medicine, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China
⨯
Zhenqiang Zhang

Roles Conceptualization, Funding acquisition

* E-mail: 13333719963@126.com

Affiliation Henan Engineering Research Center for Prevention and Treatment of Major Chronic Diseases with Chinese Medicine, Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou, Henan Province, China

https://orcid.org/0000-0002-8960-1341

⨯

Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer’s disease mice via suppressing TLR4 signaling pathway through the gut-brain axis

Yunfang Su,
Dahui Wang,
Ningning Liu,
Jiajia Yang,
Ruiqin Sun,
Zhenqiang Zhang

Published: June 2, 2023
https://doi.org/10.1371/journal.pone.0286086

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