RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb

Ananyaa Sridhar; Dawood Khan; Jessie A. Elliott; Violetta Naughton; Peter R. Flatt; Nigel Irwin; Charlotte R. Moffett

doi:10.1371/journal.pone.0286062

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Peer-reviewed

Research Article

RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb

Ananyaa Sridhar,

Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

Affiliation Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland, United Kingdom
⨯
Dawood Khan ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: d.khan@ulster.ac.uk

Affiliation Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland, United Kingdom

https://orcid.org/0000-0001-7355-1821

⨯
Jessie A. Elliott,

Roles Data curation, Methodology

Affiliation Department of Surgery, Trinity Centre for Health Sciences and St. James’s Hospital, Dublin, Ireland
⨯
Violetta Naughton,

Roles Data curation, Methodology

Affiliation Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland, United Kingdom
⨯
Peter R. Flatt,

Roles Conceptualization, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland, United Kingdom
⨯
Nigel Irwin,

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland, United Kingdom

https://orcid.org/0000-0003-4855-964X

⨯
Charlotte R. Moffett

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Biomedical Sciences Research Institute, School of Biomedical Sciences, Ulster University, Coleraine, N. Ireland, United Kingdom
⨯

RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb

Ananyaa Sridhar,
Dawood Khan,
Jessie A. Elliott,
Violetta Naughton,
Peter R. Flatt,
Nigel Irwin,
Charlotte R. Moffett

Published: May 25, 2023
https://doi.org/10.1371/journal.pone.0286062

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