Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma

Juan Hu; Cong Xie; Shangcheng Xu; Qinli Pu; Han Liu; Liping Yang; Wei Wang; Longchun Mao; Zhiqiang Li; Weixian Chen

doi:10.1371/journal.pone.0286017

Loading metrics

Open Access

Peer-reviewed

Research Article

Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma

Juan Hu ,

Contributed equally to this work with: Juan Hu, Cong Xie

Roles Methodology, Writing – original draft

Affiliations Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China, The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China
⨯
Cong Xie ,

Contributed equally to this work with: Juan Hu, Cong Xie

Roles Methodology

Affiliation Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Shangcheng Xu,

Roles Software

Affiliation The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China
⨯
Qinli Pu,

Roles Validation

Affiliation Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Han Liu,

Roles Validation

Affiliation Department of Neurology, Jiulongpo District People’s Hospital, Chongqing, China
⨯
Liping Yang,

Roles Validation

Affiliation Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
⨯
Wei Wang,

Roles Data curation

Affiliation The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China
⨯
Longchun Mao,

Roles Data curation

Affiliation The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China
⨯
Zhiqiang Li,

Roles Data curation

Affiliation The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College, Chongqing, China
⨯
Weixian Chen

Roles Conceptualization

* E-mail: 300801@cqmu.edu.cn

Affiliation Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

https://orcid.org/0000-0003-2837-2570

⨯

Liver fibrosis-derived exosomal miR-106a-5p facilitates the malignancy by targeting SAMD12 and CADM2 in hepatocellular carcinoma

Juan Hu,
Cong Xie,
Shangcheng Xu,
Qinli Pu,
Han Liu,
Liping Yang,
Wei Wang,
Longchun Mao,
Zhiqiang Li,
Weixian Chen

Published: May 25, 2023
https://doi.org/10.1371/journal.pone.0286017

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
Liver fibrosis
Is the Subject Area "Liver fibrosis" applicable to this article?

Thanks for your feedback.
MicroRNAs
Is the Subject Area "MicroRNAs" applicable to this article?

Thanks for your feedback.
Exosomes
Is the Subject Area "Exosomes" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Cancer immunotherapy
Is the Subject Area "Cancer immunotherapy" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.