Oxalic acid blocked the binding of spike protein from SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) variants to human angiotensin-converting enzymes 2

Meng Wang; Huimin Yan; Lu Chen; Yu Wang; Lin Li; Han Zhang; Lin Miao

doi:10.1371/journal.pone.0285722

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Open Access

Peer-reviewed

Research Article

Oxalic acid blocked the binding of spike protein from SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) variants to human angiotensin-converting enzymes 2

Meng Wang ,

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Formal analysis, Writing – original draft

Affiliations State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China

https://orcid.org/0000-0002-6758-5045

⨯
Huimin Yan ,

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Methodology

Affiliations Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Lu Chen ,

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Methodology

Affiliations State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Yu Wang ,

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Resources

Affiliations State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Lin Li ,

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Supervision

Affiliations State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Han Zhang ,

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Resources

* E-mail: mmmlin@tjutcm.edu.cn (LM); zhanghan0023@126.com (HZ)

Affiliations State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Lin Miao

Contributed equally to this work with: Meng Wang, Huimin Yan, Lu Chen, Yu Wang, Lin Li, Han Zhang, Lin Miao

Roles Resources, Writing – review & editing

* E-mail: mmmlin@tjutcm.edu.cn (LM); zhanghan0023@126.com (HZ)

Affiliations State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, China

https://orcid.org/0000-0003-3335-1002

⨯

Oxalic acid blocked the binding of spike protein from SARS-CoV-2 Delta (B.1.617.2) and Omicron (B.1.1.529) variants to human angiotensin-converting enzymes 2

Meng Wang,
Huimin Yan,
Lu Chen,
Yu Wang,
Lin Li,
Han Zhang,
Lin Miao

Published: May 18, 2023
https://doi.org/10.1371/journal.pone.0285722

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