Determining the clinical and cost-effectiveness of nasal sprays and a physical activity and stress management intervention to reduce respiratory tract infections in primary care: A protocol for the ‘Immune Defence’ randomised controlled trial

• Jane Vennik ,

  Roles Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: j.vennik@soton.ac.uk

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  https://orcid.org/0000-0003-4602-9805

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• Adam W. A. Geraghty,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  ⨯
• Kate Martinson,

  Roles Data curation, Project administration, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  https://orcid.org/0000-0002-8573-3718

  ⨯
• Lucy Yardley,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliations School of Psychology, University of Southampton, Southampton, United Kingdom, School of Psychological Science, University of Bristol, Bristol, United Kingdom

  ⨯
• Beth Stuart,

  Roles Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  Affiliations Primary Care Research Centre, University of Southampton, Southampton, United Kingdom, Pragmatic Clinical Trials Unit, Queen Mary University of London, London, United Kingdom

  ⨯
• Michael Moore,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  ⨯
• Nick Francis,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  ⨯
• Alastair Hay,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Centre for Academic Primary Care, Bristol Medical School, Population Health Sciences, University of Bristol, Bristol, United Kingdom

  ⨯
• Theo Verheij,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands

  ⨯
• Katherine Bradbury,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliation School of Psychology, University of Southampton, Southampton, United Kingdom

  ⨯
• Kate Greenwell,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation School of Psychology, University of Southampton, Southampton, United Kingdom

  ⨯
• Laura Dennison,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation School of Psychology, University of Southampton, Southampton, United Kingdom

  ⨯
• Sian Williamson,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation School of Psychology, University of Southampton, Southampton, United Kingdom

  ⨯
• James Denison-Day,

  Roles Project administration, Software, Writing – review & editing

  Affiliation School of Psychology, University of Southampton, Southampton, United Kingdom

  ⨯
• Ben Ainsworth,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation School of Psychology, University of Southampton, Southampton, United Kingdom

  ⨯
• James Raftery,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  ⨯
• Shihua Zhu,

  Roles Formal analysis, Funding acquisition, Methodology, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

  ⨯
• Christopher Butler,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands

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• Samantha Richards-Hall,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

  https://orcid.org/0000-0002-7665-4268

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•  [ ... ],
• Paul Little

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Primary Care Research Centre, University of Southampton, Southampton, United Kingdom

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