High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca2+ leak towards mitochondria

Yves Gouriou; Fabrice Gonnot; Mariam Wehbi; Camille Brun; Ludovic Gomez; Gabriel Bidaux

doi:10.1371/journal.pone.0285670

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Open Access

Peer-reviewed

Research Article

High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca²⁺ leak towards mitochondria

Yves Gouriou ,

Contributed equally to this work with: Yves Gouriou, Fabrice Gonnot

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: yves.gouriou@univ-lyon1.fr (YG); gabriel.bidaux@inserm.fr (GB)

Affiliations Univ-Lyon CarMeN Laboratory, Inserm U1060, Université Claude Bernard Lyon 1, INRAE, Bron, France, Hospices Civils de Lyon, Groupement Hospitalier EST, Département de Cardiologie, IHU-OPERA Bâtiment B13, Bron, France

https://orcid.org/0000-0003-2565-4935

⨯
Fabrice Gonnot ,

Contributed equally to this work with: Yves Gouriou, Fabrice Gonnot

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliations Univ-Lyon CarMeN Laboratory, Inserm U1060, Université Claude Bernard Lyon 1, INRAE, Bron, France, Hospices Civils de Lyon, Groupement Hospitalier EST, Département de Cardiologie, IHU-OPERA Bâtiment B13, Bron, France
⨯
Mariam Wehbi,

Roles Investigation

Affiliations Univ-Lyon CarMeN Laboratory, Inserm U1060, Université Claude Bernard Lyon 1, INRAE, Bron, France, Hospices Civils de Lyon, Groupement Hospitalier EST, Département de Cardiologie, IHU-OPERA Bâtiment B13, Bron, France
⨯
Camille Brun,

Roles Investigation

Affiliations Univ-Lyon CarMeN Laboratory, Inserm U1060, Université Claude Bernard Lyon 1, INRAE, Bron, France, Hospices Civils de Lyon, Groupement Hospitalier EST, Département de Cardiologie, IHU-OPERA Bâtiment B13, Bron, France
⨯
Ludovic Gomez,

Roles Funding acquisition, Writing – review & editing

Affiliations Univ-Lyon CarMeN Laboratory, Inserm U1060, Université Claude Bernard Lyon 1, INRAE, Bron, France, Hospices Civils de Lyon, Groupement Hospitalier EST, Département de Cardiologie, IHU-OPERA Bâtiment B13, Bron, France
⨯
Gabriel Bidaux

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: yves.gouriou@univ-lyon1.fr (YG); gabriel.bidaux@inserm.fr (GB)

Affiliations Univ-Lyon CarMeN Laboratory, Inserm U1060, Université Claude Bernard Lyon 1, INRAE, Bron, France, Hospices Civils de Lyon, Groupement Hospitalier EST, Département de Cardiologie, IHU-OPERA Bâtiment B13, Bron, France
⨯

High-sensitivity calcium biosensor on the mitochondrial surface reveals that IP3R channels participate in the reticular Ca²⁺ leak towards mitochondria

Yves Gouriou,
Fabrice Gonnot,
Mariam Wehbi,
Camille Brun,
Ludovic Gomez,
Gabriel Bidaux

Published: June 9, 2023
https://doi.org/10.1371/journal.pone.0285670

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