Non-invasive monitoring of neoadjuvant radiation therapy response in soft tissue sarcomas by multiparametric MRI and quantification of circulating tumor DNA—A study protocol

• Alexander Runkel ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: alexander.runkel@uniklinik-freiburg.de

  Affiliations Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany, Faculty of Medicine, Berta-Ottenstein-Programme, University of Freiburg, Freiburg, Germany

  https://orcid.org/0000-0002-5283-2322

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• David Braig,

  Roles Conceptualization, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  Affiliations Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany, Division of Hand, Plastic and Aesthetic Surgery, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany

  https://orcid.org/0000-0002-1267-0840

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• Balazs Bogner,

  Roles Data curation, Formal analysis, Software, Validation, Visualization, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Radiology, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Adrian Schmid,

  Roles Formal analysis, Software, Validation, Visualization, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Ute Lausch,

  Roles Data curation, Formal analysis, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Anika Boneberg,

  Roles Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany

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• Zacharias Brugger,

  Roles Data curation, Formal analysis, Supervision, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Medicine I, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Anja Eisenhardt,

  Roles Resources, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany

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• Jurij Kiefer,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Thomas Pauli,

  Roles Formal analysis, Software, Validation, Visualization, Writing – review & editing

  Affiliation Faculty of Medicine, Institute of Medical Bioinformatics, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Melanie Boerries,

  Roles Formal analysis, Resources, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Institute of Medical Bioinformatics, Medical Center—University of Freiburg, Freiburg, Germany

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• Hannah Fuellgraf,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Faculty of Medicine, Institute of Surgical Pathology, Medical Center—University of Freiburg, Freiburg, Germany

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• Konrad Kurowski,

  Roles Data curation, Resources, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Institute of Surgical Pathology, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Peter Bronsert,

  Roles Formal analysis, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Faculty of Medicine, Institute of Surgical Pathology, Medical Center—University of Freiburg, Freiburg, Germany, Tumorbank Comprehensive Cancer Center Freiburg, Medical Center—University of Freiburg, Freiburg, Germany, Core Facility for Histopathology and Digital Pathology, Medical Center—University of Freiburg, Freiburg, Germany

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• Jutta Scholber,

  Roles Data curation, Methodology, Resources, Supervision

  Affiliation Faculty of Medicine, Department of Radiation Oncology, Medical Center—University of Freiburg, Freiburg, Germany

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• Anca-Ligia Grosu,

  Roles Methodology, Supervision, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Radiation Oncology, Medical Center—University of Freiburg, Freiburg, Germany

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• Philipp Rovedo,

  Roles Data curation, Formal analysis, Software, Supervision, Visualization, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Radiology, Medical Physics, Medical Center-University of Freiburg, Freiburg, Germany

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• Fabian Bamberg,

  Roles Conceptualization, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Radiology, Medical Center—University of Freiburg, Freiburg, Germany

  ⨯
• Steffen Ulrich Eisenhardt ,

  Contributed equally to this work with: Steffen Ulrich Eisenhardt, Matthias Jung

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Faculty of Medicine, Department of Plastic and Hand Surgery, Medical Center—University of Freiburg, Freiburg, Germany

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•  [ ... ],
• Matthias Jung

  Contributed equally to this work with: Steffen Ulrich Eisenhardt, Matthias Jung

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Faculty of Medicine, Berta-Ottenstein-Programme, University of Freiburg, Freiburg, Germany, Faculty of Medicine, Department of Radiology, Medical Center—University of Freiburg, Freiburg, Germany

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