Plasmodium falciparum-infected erythrocyte co-culture with the monocyte cell line THP-1 does not trigger production of soluble factors reducing brain microvascular barrier function

Janet Storm; Grazia Camarda; Michael J. Haley; David Brough; Kevin N. Couper; Alister G. Craig

doi:10.1371/journal.pone.0285323

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Open Access

Peer-reviewed

Research Article

Plasmodium falciparum-infected erythrocyte co-culture with the monocyte cell line THP-1 does not trigger production of soluble factors reducing brain microvascular barrier function

Janet Storm,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0001-7812-4220

⨯
Grazia Camarda,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – review & editing

Affiliation Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Michael J. Haley,

Roles Methodology, Writing – review & editing

Affiliation Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
⨯
David Brough,

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Division of Neuroscience, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom
⨯
Kevin N. Couper,

Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

Affiliation Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom
⨯
Alister G. Craig

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

* E-mail: Alister.craig@lstmed.ac.uk

Affiliations Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0003-0914-6164

⨯

Plasmodium falciparum-infected erythrocyte co-culture with the monocyte cell line THP-1 does not trigger production of soluble factors reducing brain microvascular barrier function

Janet Storm,
Grazia Camarda,
Michael J. Haley,
David Brough,
Kevin N. Couper,
Alister G. Craig

Published: May 4, 2023
https://doi.org/10.1371/journal.pone.0285323

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Malaria
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Inflammasomes
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