SMOOTH protocol: A pilot randomised prospective intra-patient single-blinded observational study for examining the mechanistic basis of ablative fractional carbon dioxide laser therapy in treating hypertrophic scarring

• Yung-Yi Chen ,

  Contributed equally to this work with: Yung-Yi Chen, Krupali M. Patel, Rizwana Imran

  Roles Methodology, Writing – original draft, Writing – review & editing

  * E-mail: y.chen@bham.ac.uk

  Affiliations The Scar Free Foundation Centre for Conflict Wound Research, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0003-2999-3715

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• Krupali M. Patel ,

  Contributed equally to this work with: Yung-Yi Chen, Krupali M. Patel, Rizwana Imran

  Roles Methodology, Writing – original draft, Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Rizwana Imran ,

  Contributed equally to this work with: Yung-Yi Chen, Krupali M. Patel, Rizwana Imran

  Roles Writing – original draft, Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Tarek Hassouna,

  Roles Methodology, Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

  ⨯
• Ezekwe Amirize,

  Roles Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Abdulrazak Abdulsalam,

  Roles Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

  https://orcid.org/0000-0003-1267-9826

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• Jonathan Bishop,

  Roles Methodology, Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Anita Slade,

  Roles Methodology, Writing – review & editing

  Affiliations National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom

  https://orcid.org/0000-0003-2827-7741

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• Maximina Ventura,

  Roles Project administration, Writing – review & editing

  Affiliation Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Jeremy Yarrow,

  Roles Investigation

  Affiliation Welsh Centre for Burns and Plastic Surgery Morriston Hospital, Swansea, United Kingdom

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• Janet M. Lord,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations The Scar Free Foundation Centre for Conflict Wound Research, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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• Yvonne Wilson,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliations The Scar Free Foundation Centre for Conflict Wound Research, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, Birmingham Children’s Hospital, Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham, United Kingdom

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• Naiem S. Moiemen

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations The Scar Free Foundation Centre for Conflict Wound Research, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, National Institute for Health Research Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom

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