Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor

• Ravi K. Anchoori,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Oncology, Johns Hopkins University, Baltimore, MD, United States of America, Department of Pathology, Johns Hopkins University, Baltimore, MD, United States of America, Up Therapeutics LLC, Frederick, MD, United States of America

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• Vidyasagar Anchoori,

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliations Up Therapeutics LLC, Frederick, MD, United States of America, SV Chem Biotech, Edmonton, AB, Canada

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• Brandon Lam,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources

  Affiliation Department of Pathology, Johns Hopkins University, Baltimore, MD, United States of America

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• Ssu-Hsueh Tseng,

  Roles Data curation, Investigation, Methodology, Resources, Validation

  Affiliation Department of Pathology, Johns Hopkins University, Baltimore, MD, United States of America

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• Samarjit Das,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft

  Affiliation Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-4377-2823

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• Fernanda Carrizo Velasquez,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation

  Affiliation Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0003-1800-8644

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• Balasubramanyam Karanam,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Software, Visualization, Writing – review & editing

  Affiliation Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, Alabama, United States of America

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• Deepika Poddatoori,

  Roles Data curation, Investigation, Methodology, Resources, Validation, Visualization

  Affiliation Up Therapeutics LLC, Frederick, MD, United States of America

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• Ramesh Patnam,

  Roles Formal analysis, Investigation, Methodology, Resources, Validation

  Affiliation Prochem Organics, IDA Pashamylaram, Isnapur, Medak, Telangana, India

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• Michelle A. Rudek,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Oncology, Johns Hopkins University, Baltimore, MD, United States of America, Department of Medicine, Johns Hopkins University, Baltimore, MD, United States of America

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• Yung-Nien Chang ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ynchang@uptherapeutics.com (Y-NC); roden@jhmi.edu (RBSR)

  Affiliation Up Therapeutics LLC, Frederick, MD, United States of America

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• Richard B. S. Roden

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ynchang@uptherapeutics.com (Y-NC); roden@jhmi.edu (RBSR)

  Affiliations Department of Oncology, Johns Hopkins University, Baltimore, MD, United States of America, Department of Pathology, Johns Hopkins University, Baltimore, MD, United States of America

  https://orcid.org/0000-0002-2506-0195

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