Inhibition of casein kinase 2 induces cell death in tyrosine kinase inhibitor resistant chronic myelogenous leukemia cells

Ondřej Mitrovský; Denisa Myslivcová; Tereza Macháčková-Lopotová; Adam Obr; Kamila Čermáková; Šárka Ransdorfová; Jana Březinová; Hana Klamová; Markéta Žáčková

doi:10.1371/journal.pone.0284876

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Open Access

Peer-reviewed

Research Article

Inhibition of casein kinase 2 induces cell death in tyrosine kinase inhibitor resistant chronic myelogenous leukemia cells

Ondřej Mitrovský,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Department of Proteomics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic, Faculty of Science, Charles University, Prague, Czech Republic
⨯
Denisa Myslivcová,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Proteomics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯
Tereza Macháčková-Lopotová,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Department of Proteomics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯
Adam Obr ,

Roles Investigation, Writing – original draft, Writing – review & editing

* E-mail: adam.obr@uhkt.cz

Affiliation Department of Proteomics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic

https://orcid.org/0000-0003-0057-076X

⨯
Kamila Čermáková,

Roles Investigation

Affiliation Laboratory of PCR Diagnostics of Leukemias, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯
Šárka Ransdorfová,

Roles Investigation

Affiliation Department of Cytogenetics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯
Jana Březinová,

Roles Investigation

Affiliation Department of Cytogenetics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯
Hana Klamová,

Roles Resources

Affiliation Clinical Division, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯
Markéta Žáčková

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Proteomics, Institute of Hematology and Blood Transfusion, Prague 2, Czech Republic
⨯

Inhibition of casein kinase 2 induces cell death in tyrosine kinase inhibitor resistant chronic myelogenous leukemia cells

Ondřej Mitrovský,
Denisa Myslivcová,
Tereza Macháčková-Lopotová,
Adam Obr,
Kamila Čermáková,
Šárka Ransdorfová,
Jana Březinová,
Hana Klamová,
Markéta Žáčková

Published: May 4, 2023
https://doi.org/10.1371/journal.pone.0284876

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