Round-window delivery of lithium chloride regenerates cochlear synapses damaged by noise-induced excitotoxic trauma via inhibition of the NMDA receptor in the rat

• Ji Eun Choi ,

  Contributed equally to this work with: Ji Eun Choi, Nathaniel T. Carpena

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

  Affiliations Department of Otolaryngology Head and Neck Surgery, Dankook University Hospital, College of Medicine, Dankook University, Cheonan, South Korea, Multi-modality Treatment Research Center for Auditory/Vestibular Disease, College of Medicine, Dankook University, Cheonan, South Korea

  ⨯
• Nathaniel T. Carpena ,

  Contributed equally to this work with: Ji Eun Choi, Nathaniel T. Carpena

  Roles Data curation, Investigation, Methodology, Visualization

  Affiliation Multi-modality Treatment Research Center for Auditory/Vestibular Disease, College of Medicine, Dankook University, Cheonan, South Korea

  https://orcid.org/0000-0001-6984-3979

  ⨯
• Jae-Hun Lee,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea

  ⨯
• So-Young Chang,

  Roles Methodology, Supervision

  Affiliation Multi-modality Treatment Research Center for Auditory/Vestibular Disease, College of Medicine, Dankook University, Cheonan, South Korea

  ⨯
• Min Young Lee,

  Roles Conceptualization, Supervision

  Affiliations Department of Otolaryngology Head and Neck Surgery, Dankook University Hospital, College of Medicine, Dankook University, Cheonan, South Korea, Multi-modality Treatment Research Center for Auditory/Vestibular Disease, College of Medicine, Dankook University, Cheonan, South Korea

  https://orcid.org/0000-0002-6860-8042

  ⨯
• Jae Yun Jung ,

  Roles Supervision, Writing – review & editing

  * E-mail: jjkingy2k@gmail.com (JYJ); whchung@skku.edu (WHC)

  ¶‡ JYJ and W-HC also contributed equally to this work.

  Affiliations Department of Otolaryngology Head and Neck Surgery, Dankook University Hospital, College of Medicine, Dankook University, Cheonan, South Korea, Multi-modality Treatment Research Center for Auditory/Vestibular Disease, College of Medicine, Dankook University, Cheonan, South Korea

  https://orcid.org/0000-0002-1870-0748

  ⨯
• Won-Ho Chung

  Roles Supervision, Writing – review & editing

  * E-mail: jjkingy2k@gmail.com (JYJ); whchung@skku.edu (WHC)

  ¶‡ JYJ and W-HC also contributed equally to this work.

  Affiliation Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

  ⨯