Comprehensive review of safety in Experimental Human Pneumococcal Challenge

Ryan E. Robinson; Christopher Myerscough; Nengjie He; Helen Hill; Wendi A. Shepherd; Patricia Gonzalez-Dias; Konstantinos Liatsikos; Samuel Latham; Fred Fyles; Klara Doherty; Phoebe Hazenberg; Fathimath Shiham; Daniella Mclenghan; Hugh Adler; Vicki Randles; Seher Zaidi; Angela Hyder-Wright; Elena Mitsi; Hassan Burhan; Ben Morton; Jamie Rylance; Maia Lesosky; Stephen B. Gordon; Andrea M. Collins; Daniela M. Ferreira

doi:10.1371/journal.pone.0284399

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Open Access

Peer-reviewed

Research Article

Comprehensive review of safety in Experimental Human Pneumococcal Challenge

Ryan E. Robinson,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Respiratory Research Group, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom

https://orcid.org/0000-0003-0871-4780

⨯
Christopher Myerscough,

Roles Formal analysis, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Nengjie He,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Global Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Helen Hill,

Roles Conceptualization, Formal analysis, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Wendi A. Shepherd,

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Affiliation North West Health Protection Team, UK Health Security Agency, Liverpool, United Kingdom

https://orcid.org/0000-0001-9142-0219

⨯
Patricia Gonzalez-Dias,

Roles Data curation, Formal analysis, Validation, Visualization, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0002-6434-3841

⨯
Konstantinos Liatsikos,

Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Samuel Latham,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0003-2186-4652

⨯
Fred Fyles,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0002-5141-6220

⨯
Klara Doherty,

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, University of Liverpool, Liverpool, United Kingdom
⨯
Phoebe Hazenberg,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Fathimath Shiham,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Daniella Mclenghan,

Roles Conceptualization, Data curation, Investigation, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Hugh Adler,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Respiratory Research Group, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom
⨯
Vicki Randles,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Respiratory Research Group, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom
⨯
Seher Zaidi,

Roles Data curation, Methodology, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Respiratory Research Group, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom
⨯
Angela Hyder-Wright,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Clinical Research Network, Liverpool, United Kingdom
⨯
Elena Mitsi,

Roles Data curation, Investigation, Methodology, Supervision, Visualization, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
⨯
Hassan Burhan,

Roles Supervision, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Respiratory Research Group, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom
⨯
Ben Morton,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0002-6164-2854

⨯
Jamie Rylance,

Roles Formal analysis, Methodology, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi
⨯
Maia Lesosky,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Visualization, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Global Health Trials Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

https://orcid.org/0000-0002-2026-958X

⨯
Stephen B. Gordon,

Roles Conceptualization, Data curation, Supervision, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Malawi Liverpool Wellcome Research Programme, Blantyre, Malawi

https://orcid.org/0000-0001-6576-1116

⨯
Andrea M. Collins ,

Contributed equally to this work with: Andrea M. Collins, Daniela M. Ferreira

Roles Conceptualization, Data curation, Methodology, Supervision, Visualization, Writing – review & editing

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Respiratory Research Group, Liverpool University Hospitals Foundation Trust, Liverpool, United Kingdom
⨯
[ ... ],
Daniela M. Ferreira

Contributed equally to this work with: Andrea M. Collins, Daniela M. Ferreira

Roles Conceptualization, Data curation, Supervision, Writing – review & editing

* E-mail: Daniela.Ferreira@paediatrics.ox.ac.uk

Affiliations Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, Oxford Vaccine Group, University of Oxford, Oxford, United Kingdom
⨯
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Comprehensive review of safety in Experimental Human Pneumococcal Challenge

Ryan E. Robinson,
Christopher Myerscough,
Nengjie He,
Helen Hill,
Wendi A. Shepherd,
Patricia Gonzalez-Dias,
Konstantinos Liatsikos,
Samuel Latham,
Fred Fyles,
Klara Doherty

Published: May 4, 2023
https://doi.org/10.1371/journal.pone.0284399

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