GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation

He-Yu Yang; Xu Sun; Shu-Qing Zhen; Liang-Zhu Yu; Jie-Qiong Ding; Ling Liu; Min Xie; Hai-Li Zhu

doi:10.1371/journal.pone.0284332

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Open Access

Peer-reviewed

Research Article

GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation

He-Yu Yang ,

Contributed equally to this work with: He-Yu Yang, Xu Sun, Shu-Qing Zhen

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
⨯
Xu Sun ,

Contributed equally to this work with: He-Yu Yang, Xu Sun, Shu-Qing Zhen

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
⨯
Shu-Qing Zhen ,

Contributed equally to this work with: He-Yu Yang, Xu Sun, Shu-Qing Zhen

Roles Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation Matang Hospital of Traditional Chinese Medicine, Xianning, China
⨯
Liang-Zhu Yu,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
⨯
Jie-Qiong Ding,

Roles Data curation, Investigation, Methodology, Resources

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
⨯
Ling Liu,

Roles Data curation, Investigation, Methodology, Resources

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
⨯
Min Xie,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China
⨯
Hai-Li Zhu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hkhaili_zhu@163.com

Affiliation School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, China

https://orcid.org/0000-0001-7802-676X

⨯

GSK-3β inhibition alleviates arthritis pain via reducing spinal mitochondrial reactive oxygen species level and inflammation

He-Yu Yang,
Xu Sun,
Shu-Qing Zhen,
Liang-Zhu Yu,
Jie-Qiong Ding,
Ling Liu,
Min Xie,
Hai-Li Zhu

Published: April 14, 2023
https://doi.org/10.1371/journal.pone.0284332

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Pain
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