Identification of some bioactive compounds from Trignonella foenumgraecum as possible inhibitors of PPAR_ϒ for diabetes treatment through molecular docking studies, pharmacophore modelling and ADMET profiling: An in-silico study

• Olayinka Sunday Okoh ,

  Roles Conceptualization

  * E-mail: daniel.uti@fuhso.edu.ng; dan4uti@gmail.com (DEU); ookoh@aul.edu.ng (OSO)

  Affiliation Department of Chemical Sciences, Anchor University, Lagos, Nigeria

  https://orcid.org/0000-0001-6438-3379

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• AbdulbasitHaliru Yakubu,

  Roles Data curation

  Affiliation Department of Pharmaceutical Chemistry, University of Maiduguri, Maiduguri, Nigeria

  https://orcid.org/0000-0001-6018-9931

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• Abayomi Emmanuel Adegboyega,

  Roles Formal analysis, Software

  Affiliations Department of Biochemistry, Faculty of Basic Medical Science, University of Jos, Jos, Nigeria, Jaris Computational Biology Centre, Jos, Nigeria

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• Daniel Ejim Uti ,

  Roles Supervision, Writing – review & editing

  * E-mail: daniel.uti@fuhso.edu.ng; dan4uti@gmail.com (DEU); ookoh@aul.edu.ng (OSO)

  Affiliation Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria

  https://orcid.org/0000-0002-1129-1785

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• Uket Nta Obeten,

  Roles Data curation

  Affiliation Department of Chemistry/Biochemistry and Molecular Biology, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Abakaliki, Ebonyi State, Nigeria

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• Samuel Ali Agada,

  Roles Validation

  Affiliation Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Federal University of Health Sciences, Otukpo, Benue State, Nigeria

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• Folusho Oluwaloni,

  Roles Methodology

  Affiliation Department of Biotechnology, Federal Institute of Industrial Research, Oshodi, Lagos, Nigeria

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• Grace Inioluwa Johnson,

  Roles Validation

  Affiliations Jaris Computational Biology Centre, Jos, Nigeria, Faculty of Medical Sciences, College of Health Sciences, University of Jos, Jos, Nigeria

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• Leonard Paul Mela,

  Roles Writing – original draft

  Affiliation Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, Maiduguri, Nigeria

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• Rita Onyekachukwu Asomadu,

  Roles Data curation

  Affiliation University of Nigeria, Nnsuka, Nigeria

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• Opeyemi Iwaloye,

  Roles Formal analysis

  Affiliations Jaris Computational Biology Centre, Jos, Nigeria, Bioinformatics and molecular biology Unit, Department of Biochemistry, Federal University of Technology Akure, Akure, Ondo, Nigeria

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• Titilayo Omolara Johnson,

  Roles Writing – review & editing

  Affiliations Department of Biochemistry, Faculty of Basic Medical Science, University of Jos, Jos, Nigeria, Jaris Computational Biology Centre, Jos, Nigeria

  https://orcid.org/0000-0002-4230-8025

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• Obasi Uche. Orji

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria

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