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Open Access
Peer-reviewed
Research Article
The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis
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David J. Pascall ,
Contributed equally to this work with: David J. Pascall, Elen Vink
Roles Data curation, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing
Affiliations MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom, Joint Universities Pandemic and Epidemiological Research (JUNIPER) Consortium, United Kingdom
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Elen Vink ,
Contributed equally to this work with: David J. Pascall, Elen Vink
Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing
Affiliations MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom, NHS Lothian, Edinburgh, United Kingdom
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Rachel Blacow,
Roles Conceptualization, Investigation, Writing – review & editing
Affiliations MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
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Naomi Bulteel,
Roles Investigation, Writing – review & editing
Affiliation NHS Fife, Kirkcaldy, Fife, United Kingdom
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Alasdair Campbell,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Robyn Campbell,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Sarah Clifford,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Chris Davis,
Roles Conceptualization, Investigation, Methodology, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Ana da Silva Filipe,
Roles Conceptualization, Data curation, Investigation, Methodology, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Noha El Sakka,
Roles Investigation, Writing – review & editing
Affiliation NHS Grampian, Aberdeen, United Kingdom
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Ludmila Fjodorova,
Roles Investigation, Writing – review & editing
Affiliation NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
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Ruth Forrest,
Roles Investigation, Writing – review & editing
Affiliation NHS Fife, Kirkcaldy, Fife, United Kingdom
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Emily Goldstein,
Roles Investigation, Writing – review & editing
Affiliation NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
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Rory Gunson,
Roles Investigation, Writing – review & editing
Affiliation NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
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John Haughney,
Roles Project administration, Writing – review & editing
Affiliation NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
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Matthew T. G. Holden,
Roles Data curation, Methodology, Writing – review & editing
Affiliations Public Health Scotland, Edinburgh, United Kingdom, School of Medicine, University of St Andrews, St Andrews, Fife, United Kingdom
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Patrick Honour,
Roles Investigation, Writing – review & editing
Affiliation NHS Borders, Melrose, Scottish Borders, United Kingdom
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Joseph Hughes,
Roles Formal analysis, Methodology, Visualization, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Edward James,
Roles Investigation, Writing – review & editing
Affiliation NHS Borders, Melrose, Scottish Borders, United Kingdom
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Tim Lewis,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Samantha Lycett,
Roles Formal analysis, Methodology, Visualization, Writing – review & editing
Affiliation The Roslin Institute, University of Edinburgh, Midlothian, United Kingdom
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Oscar MacLean,
Roles Methodology, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Martin McHugh,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Guy Mollett,
Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliations MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
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Yusuke Onishi,
Roles Investigation, Writing – review & editing
Affiliation NHS Grampian, Aberdeen, United Kingdom
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Ben Parcell,
Roles Investigation, Writing – review & editing
Affiliation School of Life Sciences, University of Dundee, Dundee, United Kingdom
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Surajit Ray,
Roles Methodology, Writing – review & editing
Affiliation School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom
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David L. Robertson,
Roles Conceptualization, Methodology, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Sharif Shabaan,
Roles Data curation, Methodology, Writing – review & editing
Affiliation Public Health Scotland, Edinburgh, United Kingdom
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James G. Shepherd,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Katherine Smollett,
Roles Investigation, Writing – review & editing
Affiliation MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom
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Kate Templeton,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Elizabeth Wastnedge,
Roles Investigation, Writing – review & editing
Affiliation NHS Lothian, Edinburgh, United Kingdom
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Craig Wilkie,
Roles Methodology, Writing – review & editing
Affiliation School of Mathematics and Statistics, University of Glasgow, Glasgow, United Kingdom
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Thomas Williams,
Roles Conceptualization, Investigation, Methodology, Writing – review & editing
Affiliations NHS Lothian, Edinburgh, United Kingdom, Royal Hospital for Children and Young People, University of Edinburgh, Edinburgh, United Kingdom
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Emma C. Thomson ,
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: emma.thomson@glasgow.ac.uk
Affiliations MRC–University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom, London School of Hygiene and Tropical Medicine, London, United Kingdom
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The COVID-19 Genomics UK (COG-UK) Consortium
¶Membership of the COVID-19 Genomics UK (COG-UK) Consortium is provided in the Acknowledgments section.
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The SARS-CoV-2 Alpha variant was associated with increased clinical severity of COVID-19 in Scotland: A genomics-based retrospective cohort analysis
- David J. Pascall,
- Elen Vink,
- Rachel Blacow,
- Naomi Bulteel,
- Alasdair Campbell,
- Robyn Campbell,
- Sarah Clifford,
- Chris Davis,
- Ana da Silva Filipe,
- Noha El Sakka
- Published: April 13, 2023
- https://doi.org/10.1371/journal.pone.0284187
- See the preprint