High levels of pro-inflammatory SARS-CoV-2-specific biomarkers revealed by in vitro whole blood cytokine release assay (CRA) in recovered and long-COVID-19 patients

• Shayane Martins Rodrigues Gomes ,

  Contributed equally to this work with: Shayane Martins Rodrigues Gomes, Andréia Carolinne de Souza Brito

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Department of Microbiology, Parasitology and Immunology, Medical Science Faculty (FCM), Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Andréia Carolinne de Souza Brito ,

  Contributed equally to this work with: Shayane Martins Rodrigues Gomes, Andréia Carolinne de Souza Brito

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Department of Microbiology, Parasitology and Immunology, Medical Science Faculty (FCM), Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Wânia Ferraz Pereira Manfro,

  Roles Conceptualization, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Parasitology and Immunology, Medical Science Faculty (FCM), Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Marcelo Ribeiro-Alves,

  Roles Formal analysis, Writing – original draft

  Affiliation Laboratory of Clinical Research on STD/AIDS, National Institute of Infectology Evandro Chagas, Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, Brazil

  ⨯
• Roberto Stefan de Almeida Ribeiro,

  Roles Data curation, Investigation, Writing – original draft

  Affiliation Laboratory of Immunopathology, Department of General Pathology and Laboratories, FCM, UERJ, Rio de Janeiro, RJ, Brazil

  ⨯
• Mariana Soares da Cal,

  Roles Resources

  Affiliation Pulmonary and Tisiology Department, Pedro Ernesto University Hospital (HUPE), Policlínica Piquet Carneiro (PPC)/UERJ, Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0001-5537-7057

  ⨯
• Vinicius da Cunha Lisboa,

  Roles Investigation

  Affiliation Laboratory of Immunopathology, Department of General Pathology and Laboratories, FCM, UERJ, Rio de Janeiro, RJ, Brazil

  ⨯
• Daniel Paiva Barros de Abreu,

  Roles Investigation

  Affiliation Chemical Engineering Program, Cell Culture Engineering Lab (COPPE), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Leda dos Reis Castilho,

  Roles Resources

  Affiliation Chemical Engineering Program, Cell Culture Engineering Lab (COPPE), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Luís Cristóvão de Moares Sobrino Porto,

  Roles Resources

  Affiliation Histocompatibility and Cryopreservation Laboratory, Department of Histology and Embryology Institute of Biology Roberto Alcantara Gomes, UERJ, Rio de Janeiro, RJ, Brazil

  ⨯
• Thiago Thomáz Mafort,

  Roles Resources

  Affiliation Pulmonary and Tisiology Department, Pedro Ernesto University Hospital (HUPE), Policlínica Piquet Carneiro (PPC)/UERJ, Rio de Janeiro, RJ, Brazil

  ⨯
• Agnaldo José Lopes,

  Roles Resources, Writing – original draft

  Affiliation Pulmonary and Tisiology Department, Pedro Ernesto University Hospital (HUPE), Policlínica Piquet Carneiro (PPC)/UERJ, Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0001-8598-4878

  ⨯
• Silvia Amaral Gonçalves da Silva,

  Roles Conceptualization, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Parasitology and Immunology, Medical Science Faculty (FCM), Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Patrícia Maria Lourenço Dutra,

  Roles Conceptualization, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Parasitology and Immunology, Medical Science Faculty (FCM), Rio de Janeiro State University (UERJ), Rio de Janeiro, RJ, Brazil

  ⨯
• Luciana Silva Rodrigues

  Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lrodrigues.uerj@gmail.com

  Affiliation Laboratory of Immunopathology, Department of General Pathology and Laboratories, FCM, UERJ, Rio de Janeiro, RJ, Brazil

  https://orcid.org/0000-0003-0743-1009

  ⨯