Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship

Guiqin Wu; Laleh Khodaparast; Ladan Khodaparast; Matthias De Vleeschouwer; Nikolaos Louros; Rodrigo Gallardo; Pengpeng Yi; Frederic Rousseau; Joost Schymkowitz

doi:10.1371/journal.pone.0283674

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Open Access

Peer-reviewed

Research Article

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship

Guiqin Wu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

https://orcid.org/0000-0001-5422-4323

⨯
Laleh Khodaparast,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Ladan Khodaparast,

Roles Conceptualization, Investigation, Methodology, Supervision

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Matthias De Vleeschouwer,

Roles Conceptualization, Investigation

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Nikolaos Louros,

Roles Methodology

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Rodrigo Gallardo,

Roles Methodology

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Pengpeng Yi,

Roles Investigation

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Frederic Rousseau ,

Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: frederic.rousseau@kuleuven.be

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯
Joost Schymkowitz

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

Affiliations VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium
⨯

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship

Guiqin Wu,
Laleh Khodaparast,
Ladan Khodaparast,
Matthias De Vleeschouwer,
Nikolaos Louros,
Rodrigo Gallardo,
Pengpeng Yi,
Frederic Rousseau,
Joost Schymkowitz

Published: March 31, 2023
https://doi.org/10.1371/journal.pone.0283674

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Arginine
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Escherichia coli
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Protein aggregation
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