Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

Angus Li; Samuel Liu; Rennica Huang; Seungkirl Ahn; Robert J. Lefkowitz

doi:10.1371/journal.pone.0283477

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Open Access

Peer-reviewed

Research Article

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

Angus Li,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Chroma Medicine, Inc., Boston, Massachusetts, United States of America

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Samuel Liu,

Roles Data curation, Formal analysis, Validation, Visualization, Writing – review & editing

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Rennica Huang,

Roles Data curation, Visualization, Writing – review & editing

Affiliation Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Seungkirl Ahn,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

https://orcid.org/0000-0001-5681-3789

⨯
Robert J. Lefkowitz

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: lefko001@receptor-biol.duke.edu

Affiliations Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, United States of America, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, United States of America

https://orcid.org/0000-0003-1472-7545

⨯

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems

Angus Li,
Samuel Liu,
Rennica Huang,
Seungkirl Ahn,
Robert J. Lefkowitz

Published: March 24, 2023
https://doi.org/10.1371/journal.pone.0283477

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Calcium signaling
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G-protein signaling
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G protein coupled receptors
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