Analytical validation of a multi-cancer early detection test with cancer signal origin using a cell-free DNA–based targeted methylation assay

• Gregory E. Alexander ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ge_alex@pacbell.net

  Current address: Independent Statistical Consultant, San Francisco, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

  https://orcid.org/0000-0002-2442-206X

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• Wendy Lin,

  Roles Conceptualization, Methodology, Writing – review & editing

  Current address: Genentech, Inc., South San Francisco, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Fabian E. Ortega,

  Roles Data curation, Software, Writing – review & editing

  Current address: Olema Oncology, San Francisco, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Madhuvanthi Ramaiah,

  Roles Project administration, Writing – review & editing

  Current address: PrognomiQ, Inc., San Mateo, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Byoungsok Jung,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Lijuan Ji,

  Roles Investigation, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Ekaterina Revenkova,

  Roles Investigation, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Payal Shah,

  Roles Investigation, Writing – review & editing

  Current address: Roche Diagnostics, Santa Clara, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Christian Croisetiere,

  Roles Investigation, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

  https://orcid.org/0000-0002-6174-4818

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• Jennifer R. Berman,

  Roles Investigation, Supervision, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Lane Eubank,

  Roles Data curation, Software, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Gunjan Naik,

  Roles Investigation, Project administration, Validation, Writing – review & editing

  Current address: Cepheid, Sunnyvale, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Jacqueline Brooks,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Andrea Mich,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Seyedmehdi Shojaee,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Neda Ronaghi,

  Roles Data curation, Software, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Hemanshi Chawla,

  Roles Data curation, Software, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Xinyi Hou,

  Roles Data curation, Software, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Qinwen Liu,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Christopher-James A. V. Yakym,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Patriss Wais Moradi,

  Roles Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Meredith Halks-Miller,

  Roles Writing – review & editing

  Current address: Delfi Diagnostics, Palo Alto, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Alexander M. Aravanis,

  Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  Current address: Illumina, Inc., San Diego, California, United States of America

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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• Sonya Parpart-Li,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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•  [ ... ],
• Nathan Hunkapiller

  Roles Supervision, Validation, Writing – review & editing

  Affiliation GRAIL, LLC, A Subsidiary of Illumina, Inc., Currently Held Separate from Illumina, Inc., Under the Terms of the Interim Measures Order of the European Commission Dated 29 October 2021, Menlo Park, California, United States of America

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