Necrotic cardiac myocytes skew macrophage polarization towards a classically activated phenotype

Wenlong Jiang; Luigi Adamo; Kenji Lim; Scot J Matkovich; Sarah Evans; Cibele Rocha-Resende; Douglas L Mann

doi:10.1371/journal.pone.0282921

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Open Access

Peer-reviewed

Research Article

Necrotic cardiac myocytes skew macrophage polarization towards a classically activated phenotype

Wenlong Jiang ,

Roles Conceptualization, Methodology, Project administration, Writing – original draft

* E-mail: jiangwlcardio@163.com

Affiliations Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States of America, Cardiology, Jiangyin’s People Hospital, Jiangyin, Jiangsu, China

https://orcid.org/0000-0001-9948-4196

⨯
Luigi Adamo,

Roles Conceptualization, Writing – review & editing

Affiliation Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Kenji Lim,

Roles Methodology, Project administration

Affiliation Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Scot J Matkovich,

Roles Data curation, Methodology

Affiliation Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Sarah Evans,

Roles Conceptualization, Methodology

Affiliation Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States of America
⨯
Cibele Rocha-Resende,

Roles Conceptualization, Methodology

Affiliation Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States of America

https://orcid.org/0000-0002-5109-0654

⨯
Douglas L Mann

Roles Methodology, Writing – review & editing

Affiliation Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States of America
⨯

Necrotic cardiac myocytes skew macrophage polarization towards a classically activated phenotype

Wenlong Jiang,
Luigi Adamo,
Kenji Lim,
Scot J Matkovich,
Sarah Evans,
Cibele Rocha-Resende,
Douglas L Mann

Published: March 30, 2023
https://doi.org/10.1371/journal.pone.0282921

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Macrophages
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Gene expression
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Inflammation
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Phagocytosis
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Muscle cells
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Diluents
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Reactive oxygen species
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