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Open Access

Peer-reviewed

Research Article

Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE^−/− mice

Huiyan Ma ,

Contributed equally to this work with: Huiyan Ma, Libo Yang

Roles Writing – original draft, Writing – review & editing

Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China
⨯
Libo Yang ,

Contributed equally to this work with: Huiyan Ma, Libo Yang

Roles Conceptualization, Investigation, Validation

Affiliations Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China
⨯
Yajuan Liu,

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China
⨯
Ru Yan,

Roles Data curation, Project administration, Resources

Affiliations Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China
⨯
Rui Wang,

Roles Funding acquisition, Investigation, Methodology

Affiliation Clinical Medical College, Ningxia Medical University, Yinchuan, China
⨯
Peng Zhang,

Roles Investigation, Methodology, Software

Affiliation Clinical Medical College, Ningxia Medical University, Yinchuan, China
⨯
Zhixia Bai,

Roles Conceptualization, Data curation, Validation

Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China
⨯
Yuanyuan Liu,

Roles Resources, Software, Validation

Affiliation School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China
⨯
Yi Ren,

Roles Project administration, Resources, Supervision

Affiliation Clinical Medical College, Ningxia Medical University, Yinchuan, China
⨯
Yiwei Li,

Roles Conceptualization, Methodology, Software

Affiliation School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China
⨯
Xin Jiang,

Roles Software, Supervision, Validation

Affiliation Clinical Medical College, Ningxia Medical University, Yinchuan, China
⨯
Ting Wang,

Roles Data curation, Methodology, Software

Affiliation School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China
⨯
Ping Ma,

Roles Investigation, Methodology

Affiliation School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China
⨯
Qining Zhang,

Roles Data curation, Formal analysis

Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China
⨯
Aifei Li,

Roles Data curation

Affiliation Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China
⨯
Mixue Guo,

Roles Methodology

Affiliation School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China
⨯
Xiaoxia Zhang ,

Roles Formal analysis, Funding acquisition, Investigation, Methodology

* E-mail: zxx1216@163.com (XZ); jsbxn@163.com (SJ); wanghaograduate@126.com (HW)

Affiliation College of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, China
⨯
Shaobin Jia ,

Roles Funding acquisition, Project administration, Writing – review & editing

* E-mail: zxx1216@163.com (XZ); jsbxn@163.com (SJ); wanghaograduate@126.com (HW)

Affiliations Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia Medical University, Yinchuan, China, Ningxia Key Laboratory of Vascular Injury and Repair Research, Ningxia Medical University, Yinchuan, China

https://orcid.org/0000-0002-8545-1067

⨯
[ ... ],
Hao Wang

Roles Funding acquisition, Project administration, Writing – review & editing

* E-mail: zxx1216@163.com (XZ); jsbxn@163.com (SJ); wanghaograduate@126.com (HW)

Affiliations Clinical Medical College, Ningxia Medical University, Yinchuan, China, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, China
⨯
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Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE^−/− mice

Huiyan Ma,
Libo Yang,
Yajuan Liu,
Ru Yan,
Rui Wang,
Peng Zhang,
Zhixia Bai,
Yuanyuan Liu,
Yi Ren,
Yiwei Li

x

Published: March 8, 2023
https://doi.org/10.1371/journal.pone.0282685

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Atherosclerosis
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MicroRNAs
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Aorta
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Inflammatory diseases
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