Investigation of the anti-tumor mechanism of tirabrutinib, a highly selective Bruton’s tyrosine kinase inhibitor, by phosphoproteomics and transcriptomics

• Ryohei Kozaki ,

  Contributed equally to this work with: Ryohei Kozaki, Tomoko Yasuhiro

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: kozaki@ono-pharma.com

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

  https://orcid.org/0000-0002-3562-9920

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• Tomoko Yasuhiro ,

  Contributed equally to this work with: Ryohei Kozaki, Tomoko Yasuhiro

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

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• Hikaru Kato,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

  https://orcid.org/0000-0003-1802-9357

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• Jun Murai,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

  https://orcid.org/0000-0002-1322-0796

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• Shingo Hotta,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

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• Yuko Ariza,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

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• Shunsuke Sakai,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

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• Ryu Fujikawa,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

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• Takao Yoshida

  Roles Supervision, Writing – original draft, Writing – review & editing

  Affiliation Discovery and Research, Ono Pharmaceutical Co., Ltd, Osaka, Japan

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