LALAPG variant of the Human Contraception Antibody (HCA) reduces Fc-mediated effector functions while maintaining sperm agglutination activity

• Emilie Mausser ,

  Contributed equally to this work with: Emilie Mausser, Ellena Nador

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Division of Medical Sciences, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0001-5920-8808

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• Ellena Nador ,

  Contributed equally to this work with: Emilie Mausser, Ellena Nador

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Division of Medical Sciences, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Joseph A. Politch,

  Roles Formal analysis, Resources, Writing – review & editing

  Affiliation Department of Medicine, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-7022-0135

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• Michael R. Pauly,

  Roles Resources, Writing – review & editing

  Affiliation ZabBio, Inc., San Diego, California, United States of America

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• Jai G. Marathe,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medicine, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, Massachusetts, United States of America

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• Thomas R. Moench,

  Roles Resources, Writing – review & editing

  Affiliations Mapp Biopharmaceutical, Inc., San Diego, California, United States of America, Mucommune, Chapel Hill, North Carolina, United States of America

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• Larry Zeitlin,

  Roles Resources, Writing – review & editing

  Affiliations ZabBio, Inc., San Diego, California, United States of America, Mapp Biopharmaceutical, Inc., San Diego, California, United States of America

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• Kevin J. Whaley,

  Roles Resources, Writing – review & editing

  Affiliations ZabBio, Inc., San Diego, California, United States of America, Mapp Biopharmaceutical, Inc., San Diego, California, United States of America

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• Deborah J. Anderson

  Roles Conceptualization, Writing – review & editing

  * E-mail: Deborah.Anderson@BMC.org

  Affiliation Department of Medicine, Boston University Aram V. Chobanian & Edward Avedisian School of Medicine, Boston, Massachusetts, United States of America

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