Tannic acid, an IL-1β-direct binding compound, ameliorates IL-1β-induced inflammation and cartilage degradation by hindering IL-1β-IL-1R1 interaction

• Hae-Ri Lee ,

  Contributed equally to this work with: Hae-Ri Lee, Young-Jin Jeong

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Pharmacoimmunology, Integrated Research Institute of Pharmaceutical Sciences and BK21 FOUR Team for Advanced Program for Smart Pharma Leaders, College of Pharmacy, The Catholic University of Korea, Seoul, Republic of Korea

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• Young-Jin Jeong ,

  Contributed equally to this work with: Hae-Ri Lee, Young-Jin Jeong

  Roles Data curation, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Pharmacoimmunology, Integrated Research Institute of Pharmaceutical Sciences and BK21 FOUR Team for Advanced Program for Smart Pharma Leaders, College of Pharmacy, The Catholic University of Korea, Seoul, Republic of Korea

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• Joong-Woon Lee,

  Roles Data curation, Investigation

  Affiliation Laboratory of Pharmacoimmunology, Integrated Research Institute of Pharmaceutical Sciences and BK21 FOUR Team for Advanced Program for Smart Pharma Leaders, College of Pharmacy, The Catholic University of Korea, Seoul, Republic of Korea

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• JooYeon Jhun,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization

  Affiliations The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea, Lab of Translational Immuno Medicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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• Hyun Sik Na,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliations The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea, Lab of Translational Immuno Medicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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• Keun-Hyung Cho,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization

  Affiliations The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea, Lab of Translational Immuno Medicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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• Seok Jung Kim,

  Roles Methodology, Project administration

  Affiliation Department of Orthopedic Surgery, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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• Mi-La Cho,

  Roles Conceptualization, Data curation, Project administration, Supervision

  Affiliations The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, Korea, Lab of Translational Immuno Medicine, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea, Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

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• Tae-Hwe Heo

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: thhur92@catholic.ac.kr

  Affiliation Laboratory of Pharmacoimmunology, Integrated Research Institute of Pharmaceutical Sciences and BK21 FOUR Team for Advanced Program for Smart Pharma Leaders, College of Pharmacy, The Catholic University of Korea, Seoul, Republic of Korea

  https://orcid.org/0000-0003-3295-7205

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